Evaluation of Antenatal Maternal Serum Biomarkers in Pregnancies Over 41 Weeks

Hatice KANSU ÇELIK, Yaprak ENGİN ÜSTÜN, Hakan TİMUR, Selen YAMAN, Saynur YILMAZ, Elif Gül YAPAR EYI, Leyla MOLLAMAHMUTOĞLU

Ankara, Turkey

OBJECTIVE: To examine association between maternal antenatal serum biomarkers and post-term pregnancies.
STUDY DESIGN: Singleton pregnant women (n=186) managed at the Zekai Tahir Burak Women’s Health, Education and Research Hospital in Turkey from July 2010 to December 2010 were analyzed retrospectively. Maternal serum levels of PAPP-A, free β-hCG, AFP, HCG and unconjugated E3 were noted routinely in antenatal screening programs. We compared these biomarkers in pregnancies between 37 and 41 gestational weeks (n=73) and ≥41 (n=113) gestational weeks.
RESULTS: There was no statistically significant difference in maternal PAPP-A, free beta-hCG, AFP, total hCG and unconjugated E3 levels between the two groups. Although birth weights were higher in pregnant women ≥41 weeks, this difference was not considered significant (p=0.19). There were no SGA babies in the group of post-term pregnancies.
CONCLUSION: There were no statistically significant differences in maternal serum markers for pregnant women having their period of ≥41 gestational week.
Key Words: Post-term pregnancy, Maternal serum screening



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